How Fast Should Weight Loss Occur with Mounjaro?

While weight loss progress can vary based on factors like individual metabolism, starting weight, and dose, clinical trials provide insight into the expected pace of results.

First Month - Gradual Start:

• During the first four weeks, weight loss may be modest. This is because the starting dose of 2.5 mg once weekly is primarily intended to allow your body to adjust to the medication and minimise side effects like nausea.
• Weight loss in this phase is often around 1% to 3% of body weight, depending on factors like adherence to diet and activity levels [1].

Three to Six Months - More Significant Progress:

• As your dose is increased to therapeutic levels (5 mg to 15 mg once weekly), weight loss tends to accelerate.
• In clinical trials such as SURMOUNT-1, participants experienced 7.8% to 12.9% total body weight loss by 24 weeks (approximately 6 months), depending on the dose [1]

One Year or Longer - Dramatic Results

• Over 72 weeks (about 16 months), participants lost an average of 15% to 20.9% of their initial body weight, with higher doses (10 mg, 12.5 mg, and 15 mg) producing the most significant results [1]

1. Starting Dose and Escalation:

Weight loss often increases as the dose is escalated to therapeutic levels. Higher doses tend to result in more pronounced appetite suppression and calorie reduction [1].

2. Lifestyle Modifications:

Diet and exercise play a critical role. Patients who adopt a calorie-controlled diet and engage in regular physical activity typically see better results [1].

3. Individual Factors:

Age, baseline weight, metabolic rate, and adherence to treatment can affect the rate of weight loss.

A safe and sustainable weight loss rate is generally considered to be 0.45 to 0.9 kilos per week or 1% of body weight per week. While Mounjaro may accelerate this rate, especially at higher doses, it’s important to prioritise steady, sustainable progress to support long-term success and avoid complications such as muscle loss.

While rapid weight loss is exciting, it’s important to focus on the broader picture:

• Consistency Is Key: Weight loss may not be linear, with some weeks showing greater progress than others.
• Beyond the Scale: Improvements in blood sugar control, energy levels, and overall health are important milestones, even if the scale moves slowly.
• Follow-Up Care: Regular check-ins with your practitioner can help track progress, adjust dosing if needed, and address concerns.

By combining Mounjaro with lifestyle changes and focusing on long-term goals, you can achieve sustainable and meaningful results. Always consult your Mosh Medical Team to discuss your weight loss progress and ensure your treatment plan is on track.